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Figure 3 | Molecular Pain

Figure 3

From: Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability

Figure 3

Voltage-dependence of ranolazine block of hNav1.7r-WT and L858H and V1298F mutants: Dose-response curve fits. The extent of ranolazine block for each cell was determined for conditioning potentials ranging from the holding potential of -120 mV (resting block) to Vcond of -40 mV (inactivated block). Each cell was exposed to only one concentration of ranolazine. The dose-response curve for each conditioning potential (see legend symbols) was obtained by fitting a single-site binding curve to the average current block (3-9 cells/point).

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