Figure 6
From: Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability
Example responses to ranolazine from WT-expressing DRG neurons. (A) Traces illustrating the response to 1 second duration current injections of 200pA, 400pA, and 600pA both before (upper row) and after (lower row) exposure to 10 μM ranolazine are shown from a DRG neuron transfected with hNav1.7-WT channels. This phenotype, showing low frequency firing, typically occurs in 5 of 6 WT-expressing DRG neurons chosen for recording. (B) Traces in the same format as panel A recorded from a high frequency firing WT-expressing DRG neuron.