From: Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability
 | WT | L858H | V1298F |
---|---|---|---|
Vhold = -120 mV | 175 μM, R = 0.44 | 700 μM, R = 0.96 | 110 μM, R = 0.55 |
Vcond = -100 mV | 107 μM, R = 0.79 | 164 μM, R = 0.93 | 120 μM, R = 0.83 |
Vcond = -80 mV | 53 μM, R = 0.92 | 60 μM, R = 0.98 | 81 μM, R = 0.61 |
Vcond = -60 mV | 34 μM, R = 0.99 | 31 μM, R = 0.97 | 39 μM, R = 0.74 |
Vcond = -40 mV | 31 μM, R = 0.99 | 21 μM, R = 0.99 | 20 μM, R = 0.99 |