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Figure 5 | Molecular Pain

Figure 5

From: Changes in Aβ non-nociceptive primary sensory neurons in a rat model of osteoarthritis pain

Figure 5

Aβ-fiber low threshold mechanoreceptors. Scatter plots of AP properties of individual neurons in control animals, and in OA animals at one month after model induction. The parameters that bear most of the documented changes are presented, including A AP duration at base, B AP rise time, C AP fall time, D AP amplitude, E/F maximum rising and falling rates. In each case the median (horizontal line) is superimposed. The D'Agostino and Pearson omnibus normality test was run in all data groups in order to assign the data to parametric or non-parametric t tests. APD (AP duration at base) was significantly wider in the OA group (1.07 ± 0.02 ms, N = 79 in OA vs. 0.98 ± 0.03 ms, N = 83 in control; P = 0.028; Mann-Whitney U-test). AP rise time was significantly longer in the OA group (0.45 ± 0.01 ms, N = 79 in OA vs. 0.39 ± 0.01 ms, N = 83 in control; P < 0.001; Student's t-test). MRR (Maximum rising rate) was significantly slower in the OA group (254.3 ± 6.22 mV/ms, N = 79 in OA vs. 291.9 ± 9.41 mV/ms, N = 83 in control; P = 0.001; Student's t-test).

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