Figure 5

Polysynaptic afferent fiber-evoked EPSCs in SG neurons of control and cancer-bearing mice. Representative traces of polysynaptic Aδ fiber-evoked EPSCs elicited by the stimulation of the dorsal root at 20 Hz in control (left) and cancer-bearing mice (right) (A). There was no significant difference in the amplitude of polysynaptic Aδ fiber-evoked EPSCs between control (n = 26) and cancer-bearing (n = 34) mice (B). Representative traces of polysynaptic C fiber-evoked EPSCs (indicated by arrowheads) elicited by the stimulation of the dorsal root at 2 Hz in control (left) and cancer-bearing (right) mice (C). The neurons shown in C received polysynaptic C fiber-evoked EPSCs and Aδ fiber-evoked ones. There was no significant difference in the amplitude of polysynaptic C fiber-evoked EPSCs between control (n = 8) and (n = 14) cancer-bearing mice, P > 0.05 (unpaired t-test) (D). Values represent means ± S.E.M.