Icilin-induced cold hypersensitivity is inhibited by the iPLA2 inhibitor, BEL. A. Ipsilateral paw withdrawal latencies in lightly restrained rats at various times after intra-plantar administration of 0.6, 6 or 60 μg icilin or vehicle alone. B. Prior administration of 30-300 μg BEL dose dependently inhibited the cold hypersensitivity induced by 60 μg icilin. Data show mean ± SEM for 6 rats/group. * p < 0.05, ** p < 0.01, *** p < 0.001 vs vehicle. In B, † p < 0.05, †† p < 0.01 when compared with vehicle/icilin treated group.