Figure 7From: The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity TRPA1 agonists AITC and cinnamaldehyde evoke cold hypersensitivity. Intraplantar injection of either AITC (100 μg) or cinnamaldehyde (50 μg) evoked marked cold hypersensitivity in the ipsilateral paw of lightly restrained wild-type mice but had no effect when administered to Trpa1-/- mice. Data show mean ± SEM for 6 mice/group. *** p < 0.001 vs pre-dose latencies.Back to article page