Figure 7

Effects of morphine and duloxetine on EF ₅₀ s of rats at 8 weeks after ligation of the TASM. The EF₅₀s were below 1 g prior to administration of drugs, indicating the presence of mechanical allodynia. a. Morphine was injected s.c. at 0.4, 4 and 8 mg/kg (1 ml/kg, n = 5 per dose). Morphine produced significant and dose-dependent increases in EF₅₀s tested at 45 min after injection (ANOVA, P < 0.01). b. Duloxetine was injected i.p. at 0.4, 4, 10 and 20 mg/kg (1 ml/kg, n = 5 per dose). Administration of duloxetine produced significant and dose-dependent increases in EF₅₀s tested at 60 min after injection (ANOVA, P < 0.01).