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Table 2 Labor pain behavior related outcomes according to GCH1 haplotypes

From: Different SNP combinations in the GCH1 gene and use of labor analgesia

  

Non-carriers

(n = 481)

Heterozygous

(n = 180)

Homozygous

(n = 15)

Cervical dilation at arrival to the delivery unita, cm

 

4.3 ± 2.5

4.1 ± 2.3

5.7 ± 2.2*

Cervical dilation at request of epidural analgesiab, cm

 

5.8 ± 1.9

5.3 ± 2.0

6.3 ± 2.3

Use of labor analgesia, n (%)

No use

44 (9.1%)

17 (9.4%)

1 (6.7%)

 

Nitrous oxide

396 (82.3%)

143 (79.4%)

12 (80.0%)

 

Acupuncture

155 (32.2%)

62 (34.4%)

6 (40.0%)

 

Epidural analgesia

159 (33.1%)

52 (28.9%)

7 (46.7%)

 

Second line analgesia

249 (51.8%)

92 (51.1%)

11 (73.3%)

  1. *p = 0.033 in comparison to heterozygous carriers and non-carriers of the GCH1 haplotype, ANOVA adjusted for parity.
  2. a Data missing in 81 subjects
  3. b Data based on 159 non-carriers, 52 heterozygous and 7 homozygous carriers of the GCH1 haplotype.