From: Different SNP combinations in the GCH1 gene and use of labor analgesia
Use of second line labor analgesia | Unadjusted OR | 95% CI | Adjusted OR | 95% CI | ||
---|---|---|---|---|---|---|
Parity | Parous | 130 (34.9%) | 1 | 1 | ||
Nulliparous | 222 (73.3%) | 5.12*** | 3.67 - 7.14 | 2.68*** | 1.73 - 4.16 | |
Height | 0.98 | 0.96 - 1.00 | 0.98 | 0.96 - 1.00 | ||
Start of labor | Spontaneous | 291 (50.2%) | 1 | 1 | ||
Induced | 61 (63.5%) | 1.73* | 1.11 - 2.70 | 0.63 | 0.32 - 1.23 | |
Cervical dilation at arrival to the delivery unit, cma | > 5 | 83 (36.9%) | 1 | 1 | 0.79 - 0.97 | |
2-4 | 178 (56.9%) | 2.26*** | 1.59 - 3.20 | 1.34 | 0.85 - 2.13 | |
0-1 | 45 (78.9%) | 6.42*** | 3.21 - 12.82 | 2.46* | 1.05 - 5.76 | |
Duration of laborb | 0-2 hours | 32 (17.6%) | 1 | 1 | ||
2-5 hours | 74 (45.1%) | 3.85*** | 2.36 - 6.29 | 3.33*** | 1.92 - 5.80 | |
5-10 hours | 109 (66.1%) | 9.12*** | 5.54 - 15.03 | 7.13*** | 3.87 - 13.13 | |
> 10 hours | 134 (87.0%) | 31.41*** | 17.14 - 57.53 | 16.53*** | 7.68 - 35.62 | |
GCH1 pain protecting genotype | Absent | 249 (51.8%) | 1 | 1 | ||
Heterozygous | 92 (51.1%) | 0.97 | 0.69 - 137 | 1.25 | 0.80 - 1.97 | |
Homozygous | 11 (73.3%) | 2.56 | 0.80 - 8.16 | 5.11* | 1.09 - 23.96 |