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Figure 5 | Molecular Pain

Figure 5

From: Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin

Figure 5

Arc/Arg3.1 is expressed in a subpopulation of superficial dorsal horn neurons with a preference for neurons containing enkephalin. A-E, Fluorescent micrographs showing neurons in the superficial dorsal horn that express Arc/Arg3.1 mRNA (A-C) or protein (D and E) and markers that identify neurons expressing the neurokinin-1 receptor (NK1), protein kinase C gamma (PKC-γ), Calbindin, GAD67 mRNA (GABAergic neurons), or preproenkephalin mRNA (enkephalinergic neurons) respectively. The following nociceptive stimuli were used. A, CFA, survival time 1.5 hrs, B and C: Mustard oil 25% gauze wrapped, survival time 1 h, D and E, Mustard oil 25% gauze wrapped, survival time 2 h. Arrow heads indicate Arc/Arg3.1 labeled neurons that also express one of the markers mentioned above. Scale bar: 50 μm.

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