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Figure 1 | Molecular Pain

Figure 1

From: Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization?

Figure 1

Scheme to show interactions between primary afferents, dorsal horn neurons microglia and astroctyes in the context of chronic pain. Literature citations supporting the illustrated interactions include; IL-1β, MCP-1/CCL-2 and TNF-α in acute and chronic excitation of primary afferents [3–9]; MCP-1/CCL-2, ATP, BDNF and fractalkine in microglial activation [13, 18, 59, 60, 64, 65]; autocrine actions of TNF-α in microglia [120]; IL-1β release from microglia [55, 57] and its actions on neurons [30, 98]; BDNF release from microglia and its actions on neurons [14, 21, 24, 25, 61]; role of MCP-1/CCL-2 in astrocyte-neuron interactions [38], actions of TNF-α on astrocytes and neurons [30, 58]. To the best of our knowledge actions of IL-1b on astrocytes in spinal cord has not been demonstated but there is evidence for this interaction in other neuronal systems [97, 121].

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Molecular Pain

ISSN: 1744-8069

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