Figure 3

Neuron types and injury footprints produced by CCI and BDNF. A-E Firing patterns of tonic, delay, irregular, phasic and transient neurons in response to depolarizing current commands. F. Injury footprint produced by CCI. Neuron types are listed across the top of the scheme and four indices of excitatory synaptic transmission are listed to the left. Neuron specific parameters increased (↑; such as sEPSC amplitude in delay neurons) are coded green. Neuron specific parameters decreased (↓; such as sEPSC amplitude in tonic neurons) are coded red. Data from [107]. nd = not determined. G. Injury footprint produced by BDNF. Neuron types are listed across the top of the scheme and four indices of excitatory synaptic transmission are listed to the left. Neuron specific parameters increased (↑; such as sEPSC amplitude in delay neurons) are coded green. Neuron specific parameters decreased (↓; such as sEPSC amplitude in tonic neurons) are coded red. Data from [24]. H. Overlay of the injury footprints from F and G, similarities between the actions of CCI and BDNF treatment show up as clear green or red squares. Yellow squares illustrate the few parameters which appear to be altered in a different way by BDNF compared to CCI. 2 out 20 (10%) of squares are yellow. I. Injury footprint produced by IL-1β. Neuron types are listed across the top of the scheme and indices of excitatory synaptic transmission SEPSC amplitude and frequency are listed to the left. Neuron specific parameters increased (↑) are coded green. Neuron specific parameters decreased (↓) are coded red. J. Overlay of IL-1β injury footprint from I with sEPSC amplitude and frequency data from A. Yellow squares illustrate the parameters which appear to be altered in a different way by IL-1β compared to CCI. 5 out of 10 (50%) of squares are yellow. This analysis indicates that the consequences of CCI are mimicked more accurately by BDNF than by IL-1β.