Figure 4
Analysis of the effects of BDNF on mEPSCs of tonic neurons (in vitro). A. Superimposed recordings of 3 min of mEPSC activity in a control tonic neuron, average of events presented as superimposed white trace. B. Similar superimposed recordings from a tonic neuron in a BDNF-treated culture. C. Averaged events from the neurons illustrated in A and B. D. Averaged events normalized to control size. Note marked increased rate of decay of current. E. Distribution histogram (1 pA bins) for amplitudes of 1100 mEPSCs from control tonic neurons. Fit of the data to three Gaussian distributions represented by black lines. F. Similar histogram and fit to three Gaussian functions for 877 mEPSCs from BDNF-treated neurons: Insets in E and F. Graphs to show effect of number of Gaussian fits (peaks) on the value of χ2 divided by the number of degrees of freedom. G: Superimposition of the three Gaussian peaks obtained in E with those obtained in F. Modified from reference [24] and reproduced with permission of the Physiological Society.