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Figure 5 | Molecular Pain

Figure 5

From: Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization?

Figure 5

Analysis of the effects of CCI on mEPSCs of tonic neurons ( ex vivo ). A. Average mEPSC's in tonic neurons modelled from amplitude and τ values published in [107]. Dark line = average of 325 mEPSC from sham operated animals, red line = average of 175 mEPSC from animals subject to CCI. B. Data from A normalized and replotted. C. Distribution histogram (1 pA bins) for amplitudes of 325 mEPSCs from tonic neurons in sham operated animals. Fit of the data to two Gaussian distributions represented by black lines. D. Similar histogram and fit to two Gaussian functions for 175 mEPSCs in tonic neurons from animals subject to CCI: Insets in C and D. Graphs to show effect of number of Gaussian fits (peaks) on the value of χ2 divided by the number of degrees of freedom. Note that no improvement of fit is seen when a third Gaussian is introduced. E: Superimposition of the two Gaussian peaks obtained in C with those obtained in D.

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Molecular Pain

ISSN: 1744-8069

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