Figure 7
Analysis of the effects of CCI on mEPSCs of delay neurons ( ex vivo ). A. Average mEPSC's in delay neurons modelled from amplitude and τ values published in [107]. Dark line = average of 731 mEPSC from sham operated animals, red line = average of 748 mEPSC from animals subject to CCI. B. Data from A normalized and replotted. C. Distribution histogram (1 pA bins) for amplitudes of 731 mEPSCs from delay neurons in sham operated animals. Fit of the data to two Gaussian distributions represented by black lines. D. Similar histogram and fit to two Gaussian functions for 748 mEPSCs in tonic neurons from animals subject to CCI: Insets in C and D. Graphs to show effect of number of Gaussian fits (peaks) on the value of χ2 divided by the number of degrees of freedom. Note that no improvement of fit is seen when a third Gaussian is introduced. E. Superimposition of the two Gaussian peaks obtained in C with those obtained in D. Inset, comparison of area under curves for the two peaks. F. Data for sham and CCI groups' mEPSCs > 25 pA replotted and compared on the same axes. G. Comparison of number of mEPSC events in sham and CCI delay cells larger than 25 pA.