Table 1 Comparison of the effects of CCI and BDNF on the characteristics of miniature excitatory postsynaptic currents (mEPSC) in tonic and delay neurons.
| Â | Â | CCI | BDNF | |||
|---|---|---|---|---|---|---|
| Â | Â | ex vivo experiments | Organotypic culture experiments | |||
Tonic | τ (mEPSC decay) | ↓ 35% | ↓ 35% | |||
| Â | Â | Peak 1 | Peak 2 | Peak 1 | Peak 2 | Peak 3 |
(sham or control) | mEPSC peak amplitudes | 15 | 10.8 | 12 | 19.7 | 35.7 |
(CCI or BDNF) | mEPSC peak amplitudes | 11.6 | 8.7 | 7.3 | 11 | 19.4 |
|  | Change in mEPSC peak ampltudes | ↓23% | ↓19% | ↓39% | ↓44% | ↓46% |
|  | Change in overall mEPSC amplitude | ↓23% | ↓18% | |||
| Â | Â | CCI | BDNF | |||
Delay | τ (mEPSC decay) | Unchanged | ↑38% | |||
| Â | Â | Peak 1 | Peak 2 | Peak 1 | Peak 2 | Peak 3 |
(sham or control) | mEPSC peak amplitudes | 8.5 | 14.7 | 9.3 | 12.7 | 19 |
(CCI or BDNF) | mEPSC peak amplitudes | 7.6 | 10.1 | 8.1 | 12.5 | 20.5 |
|  | Change in mEPSC peak ampltudes | ↓11% | ↓31% | ↓13% | ↓1.5% | ↑8% |
|  | Change in overall mEPSC amplitude | ↑12% Due to appearance of small group of high amplitude responses (Figure 7) | ↑10% Due to appearance of small group of high amplitude responses (Figure 6) | |||