Figure 1From: Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior Knee Joint Temperature Increase is Blocked by ROS Scavenger PBN. Right and left knee joint temperature (°C) at baseline and 4 h after k/c induction of left knee joint inflammation (Arth) in rats pre-treated i.p. with saline (n = 4) or the ROS scavenger, PBN (n = 4). The PBN provided protection from significant increase in knee joint temperature typical of this arthritis model. Temperature increase in both knees is indicative of a centrally mediated "mirror" effect on regional blood flow. Core body temperature measured with a rectal thermometer was not increased over baseline.Back to article page