Knee Joint Temperature Increase is Blocked by ROS Scavenger PBN. Right and left knee joint temperature (°C) at baseline and 4 h after k/c induction of left knee joint inflammation (Arth) in rats pre-treated i.p. with saline (n = 4) or the ROS scavenger, PBN (n = 4). The PBN provided protection from significant increase in knee joint temperature typical of this arthritis model. Temperature increase in both knees is indicative of a centrally mediated "mirror" effect on regional blood flow. Core body temperature measured with a rectal thermometer was not increased over baseline.