Figure 2
Menthol responses in menthol-sensitive/capsaicin-insensitive and menthol-sensitive/capsaicin-sensitive neurons following prolonged menthol application. A) Time course of the changes of intracellular Ca2+ concentrations ([Ca2+]) in MS/CI neurons (n = 22) following the application of 100 μM menthol for 5 min. B) Menthol responses in MS/CI neurons expressed as percentages of maximal Δ[Ca2+]/[Ca2+]0 values or maximal ΔF/Fo values. C) Time course of menthol responses (ΔF/Fo) in MS/CI (n = 22) and MS/CS (n = 18) neurons during 5-min application of 100 μM menthol. D) Same as C except menthol responses at each time point are expressed as percent of peak menthol responses. In each experiment, menthol was continuously applied for 5 min. Capsaicin-sensitivity for each cell was tested 10 min after the termination of menthol applications. The horizontal bar in each figure indicates 5-min menthol application. Data are mean ± SEM; *P < 0.05.