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Table 1 Lack of change in desensitization onset of P2X3 receptors by the calcineurin inhibitor FK-506

From: Familial hemiplegic migraine CaV2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

Phenotype Current τ fast n
WT 81 ± 6 ms 14
WT + FK-506 (5 μM) 71 ± 7 ms 17
KI 91 ± 8 ms 18
KI + FK-506 (5 μM) 100 ± 9 ms 16
  1. Data refers to the first time constant of current decay evoked by α,β-meATP (10 μM) taken as index of desensitization.