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Table 1 Lack of change in desensitization onset of P2X3 receptors by the calcineurin inhibitor FK-506

From: Familial hemiplegic migraine CaV2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

Phenotype

Current Ï„ fast

n

WT

81 ± 6 ms

14

WT + FK-506 (5 μM)

71 ± 7 ms

17

KI

91 ± 8 ms

18

KI + FK-506 (5 μM)

100 ± 9 ms

16

  1. Data refers to the first time constant of current decay evoked by α,β-meATP (10 μM) taken as index of desensitization.
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Molecular Pain

ISSN: 1744-8069

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