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Figure 3 | Molecular Pain

Figure 3

From: Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats

Figure 3

Attenuation of mechanical TMJ allodynia by anticonvulsant retigabine in a dose-dependent manner. Drugs (Mor: morphine and RTG: retigabine) of different concentrations were administered to rats with TMJ inflammation by intraperitoneal (i.p) injection at time 0. The withdrawal threshold was measured at 15, 30, 60 and 120 min after drug treatment, with morphine as a positive control. Statistical significance of p < 0.05 (two-way ANOVA followed by Bonferroni post hoc) was obtained for the period 15-60 min for the groups CFA + morphine (5 mg/kg), and CFA + retigabine (7.5 mg/kg or 2.5 mg/kg), as compared with the group CFA + vehicle.

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Molecular Pain

ISSN: 1744-8069

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