Retigabine reduced allodynia reversed by the blocker XE991. RTG (retigabine) at 7.5mg/kg attenuated the inflamed TMJ allodynia, and the effect was reversed by XE991 (3 mg/kg or 1 mg/kg) in a dose- and time-dependent manner. XE991 alone (3 mg/kg) had no effect on the head withdrawal threshold in TMJ inflammation. Statistical significance of p < 0.05 (two-way ANOVA followed by Bonferroni post-test) was obtained for the period 15-60 min for the group CFA + RTG 7.5 mg/kg, as compared with CFA + vehicle; and was also obtained for the two groups CFA + RTG 7.5 mg/kg + XE 3 mg/kg, and CFA + RTG 7.5 mg/kg + XE 1 mg/kg, as compared with the group of CFA + RTG 7.5 mg/kg. XE: XE991, RTG: retigabine. The plus sign (+) in the legend indicates CFA treatment.