Figure 1From: Regulation of AMPA receptors in spinal nociception Pathways of AMPA receptor trafficking. AMPA receptors may cycle between intracellular stores and the cell surface rapidly and constitutively. AMPA receptors in plasma membrane may exchange between the extra-synaptic and synaptic membrane in a manner of lateral diffusion. The receptor-cycling event and lateral diffusion can regulate the number of AMPA receptors in synapses and further changes the synapse strength. PSD, post-synaptic density.Back to article page