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Figure 2 | Molecular Pain

Figure 2

From: Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain. ketamine, astrocytic inhibitor and pain

Figure 2

Effects of drugs administration on SNL-induced NR1 phosphorylation. Phosphorylated NR1 (pNR1) level was much higher in SNL-Saline group than that of Sham-Saline group (* P < 0.05). Intrathecal ketamine (100 μg/kg) down-regulated pNR1 level compared with that of SNL-Saline group. Coadministration further inhibited pNR1 expression than that of individual ketamine injection. Furthermore, pNR1 returned to high level at 1 d after individual ketamine injection. However, pNR1 remained low at 1 d in the coadministration group compared with that of individual ketamine injection. Additionally, LAA application alone has no obvious effects on SNL-induced NR1 phosphorylation. *, # and $ each indicates statistically significant difference with P < 0.05 between groups.

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Molecular Pain

ISSN: 1744-8069

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