Effects of HDACI on thermal nociception on naïve mice. Naïve mice treated with i.t. SAHA (25 μg) or VPA (0.5 mg) were tested for their hindpaw response to a noxious heat beam for indicated time. Mean values + s.e. of PWL from 8 animals each group were presented. No significance was revealed for comparison among tested period either at the ipsilateral or contralateral side.