Table 2 Morphometry of subpopulations of DRG neurons with strong immunoreactivity (IR) for ATP7A and CTR1 in tissues from control and oxaliplatin-treated animals
From: Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue
Animal Group | Copper transporter | Frequency of IR neurons (%) | Small-sized cells ( < 750 μm2) (%) | Medium-sized cells (750-1750 μm2) (%) | Large-sized cells ( > 1750 μm2) (%) | Mean cell body area (μm2) |
|---|---|---|---|---|---|---|
Control | ATP7A | 35.1 ± 2.9 | 64.2 ± 6.9 | 29.1 ± 4.7 | 6.7 ± 2.5 | 767 ± 88 |
|  | CTR1 | 10.9 ± 1.8†| 2.0 ± 1.3†| 39.9 ± 15.9 | 58.2 ± 16.1†| 1936 ± 278†|
Oxaliplatin treatment | ATP7A | 33.6 ± 2.3 | 70.5 ± 4.0 | 27.1 ± 3.7 | 2.4 ± 1.3 | 641 ± 39 |
|  | CTR1' | 11.3 ± 3.5 | 5.2 ± 2.0 | 66.4 ± 5.5* | 28.5 ± 5.5* | 1461 ± 64* |