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Table 2 Morphometry of subpopulations of DRG neurons with strong immunoreactivity (IR) for ATP7A and CTR1 in tissues from control and oxaliplatin-treated animals

From: Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue

Animal Group Copper transporter Frequency of IR neurons
(%)
Small-sized cells
( < 750 μm2) (%)
Medium-sized cells
(750-1750 μm2) (%)
Large-sized cells
( > 1750 μm2) (%)
Mean cell body area
(μm2)
Control ATP7A 35.1 ± 2.9 64.2 ± 6.9 29.1 ± 4.7 6.7 ± 2.5 767 ± 88
  CTR1 10.9 ± 1.8 2.0 ± 1.3 39.9 ± 15.9 58.2 ± 16.1 1936 ± 278
Oxaliplatin treatment ATP7A 33.6 ± 2.3 70.5 ± 4.0 27.1 ± 3.7 2.4 ± 1.3 641 ± 39
  CTR1' 11.3 ± 3.5 5.2 ± 2.0 66.4 ± 5.5* 28.5 ± 5.5* 1461 ± 64*
  1. Values represent the mean ± standard deviation of determinations in 4 to 6 animals per group. P < 0.01 for comparison with ATP7a control group; * P < 0.01 for comparison with CTR1 control group.