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Table 1 Immune and inflammatory response genes down-regulated in the DRG by intraplantar CFA

From: Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping

Gene Symbol

Gene Name

Fold

Adamts12

ADAM metallopeptidase with thrombospondin type 1 motif, 12

-1.6

Alox15

arachidonate 15-lipoxygenase

-2.1

Bcl6

B-cell CLL/lymphoma 6

-1.6

Btk

Bruton agammaglobulinemia tyrosine kinase

-1.5

Ca6

carbonic anhydrase VI

-1.6

Casp8

caspase 8, apoptosis-related cysteine peptidase

-1.5

Cd22

CD22 molecule

-2.2

Cd52

CD52 molecule

-1.9

Cnr2

cannabinoid receptor 2 (macrophage)

-1.7

Colec12

collectin sub-family member 12

-1.9

Cpa3

carboxypeptidase A3 (mast cell)

-2.4

Ctgf

connective tissue growth factor

-1.6

Ctse

cathepsin E

-1.8

Cybb

cytochrome b-245, beta polypeptide

-1.6

Efna4

ephrin-A4

-1.5

F13a1

coagulation factor XIII, A1 polypeptide

-1.8

Fgr

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

-1.5

Hcls1

hematopoietic cell-specific Lyn substrate 1

-1.8

Hecw2

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

-1.6

Ikzf1

IKAROS family zinc finger 1 (Ikaros)

-1.8

Il1r2

interleukin 1 receptor, type II

-1.6

Il21r

interleukin 21 receptor

-1.5

Il2rb

interleukin 2 receptor, beta

-1.6

Klra7

killer cell lectin-like receptor, subfamily A, member 7

-1.6

Lox

lysyl oxidase

-1.6

Npas2

neuronal PAS domain protein 2

-1.7

Odz4

odz, odd Oz/ten-m homolog 4 (Drosophila)

-1.5

Pdgfrl

platelet-derived growth factor receptor-like

-1.7

Pla2g4a

phospholipase A2, group IVA (cytosolic, calcium-dependent)

-1.9

Ptgs1

prostaglandin-endoperoxide synthase 1

-1.9

Rara

retinoic acid receptor, alpha

-1.6

Si

sucrase-isomaltase (alpha-glucosidase)

-1.6

Sit1

signaling threshold regulating transmembrane adaptor 1

-1.5

Spag16

sperm associated antigen 16

-1.6

Tnfrsf14

tumor necrosis factor receptor superfamily, member 14

-1.7

Tpsb2

tryptase beta 2

-1.5

Xdh

xanthine dehydrogenase

-1.9