CPM-fibers exhibit decreased heat thresholds in inflamed TRPV-/- mice. A) Only C57/BL6 mice have reduced latencies when responding to a radiant heat stimulus to the plantar surface of the hindpaw after inflammation. As previously described, in TRPV1-/- mice, the response latency to this stimulus is not different after inflammation. B) CPM-fibers that do not stain for TRPV1 have reduced heat thresholds after inflammation in TRPV1-/- mice. C) Unexpectedly, the firing rates of CPM-fibers to stimulation with a heat ramp are only significantly increased after inflammation in C57/BL6 animals. D) The mechanical response properties of CPM-fibers were not different after inflammation in both C57/BL6 and TRPV1-/- mice.