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Figure 5 | Molecular Pain

Figure 5

From: Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers

Figure 5

Example of TRPV1-positive CPM-fiber following inflammation. Light micrographs of a L3 DRG from the ex vivo recording preparation containing a neurobiotin-filled polymodal C-fiber (CPM) immunoreactive for TRPV1. A) A Neurobiotin labeled (green) CPM neuron (arrows) recovered from the ex vivo preparation overlaps with TRPV1 immunoreactivity (red). B) Immunostaining for TRPV1 (red) shows that the same neurobiotin-filled CPM neuron in A is immunopositive for TRPV1 (arrows). Scale bar, 20 μm.

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