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Table 1 TRPV1 and IB4 staining of identified CPM-fibers in naïve and inflamed mice

From: Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers

CPM fibers

IB4-positive ratio

TRPV1-positive ratio

Combined naïve C3H/BL6 and C57/BL6

31/38

0/34

Combined inflamed C3H/BL6 and C57/BL6

30/36

4/36

  1. Identified C-polymodal fibers in naïve and inflamed wildtype animals for IB4 binding and TRPV1 immunoreactivity. Only after inflammation are TRPV1 positive CPM-fibers observed.
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Molecular Pain

ISSN: 1744-8069

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