Figure 8

The efficacy of ZJ43 and SLx-3095-1 in CeLC 24 hours post peripheral inflammation. Whole cell recordings were conducted to investigate the inhibitory efficacy of ZJ43 (0.1 μM) and SLx-3095-1 (0.5 μM) in the CeLC 24 hours post peripheral inflammation. (A) Representative trace of the ZJ43 effect. (C) Average data for experiments shown in A in which ZJ43 alone had very little effect on eEPSCs (5% reduction, p < 0.01, n = 10, paired Student's t-test in contrast to its effect in controls (Figure 4). (B) SLx-3095-1 significantly reduced the amplitude of the eEPSCs in the CeLC region (n = 12), average data shown in (D). Data presented as mean ± SEM percent control; *p ≤ 0.05 vs. control, paired Student's t-test. Recordings were in Mg²⁺ free ACSF.