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Figure 8 | Molecular Pain

Figure 8

From: Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones

Figure 8

Upregulation of proportion of thrombin-responsive cells by neurotrophic factors. A. Percentage of neurons in which PKCε translocation was observed following exposure to thrombin (100 nM, 30 s) (white bars) was increased significantly by NGF (100 ng/ml, 3 days, p < 0.05) and by neurturin (NTN, 50 ng/ml, 3 days, P < 0.01). Effects were partially additive (final bar). Grey bars show percentage of neurons that were IB4+; neurturin caused significant upregulation of expression of thrombin responsiveness in the IB4+ population but NGF had no significant effect. *; p < 0.05; **, p < 0.01 compared to control.

B. Deletion of PAR1 reduces but does not eliminate responsiveness to thrombin.

C. Deletion of PAR2 does not affect proportion of neurons responsive to thrombin.

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