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Table 1 Summary of basic electrophysiological parameters of ACC layer II/III pyramidal neurons in adult mice in vivo

From: In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice

  RS cells (n = 5) IM cells (n = 31) IB cells (n = 14)
Ratio 10 62 28
RMP (mV) -68.4 ± 2.2 -72.0 ± 1.9 -67.1 ± 2.3
Spontaneous AP threshold (mV) -46.1 ± 2.9 -48.3 ± 1.4 -44.2 ± 2.0
Oscillation Frequency (Hz) 0.4 ± 0.08 0.41 ± 0.04 0.48 ± 0.04
Spike Height (mV) 56.1 ± 7.5 59.0 ± 2.3 57.5 ± 3.2
Spike Half Width (ms) 1.40 ± 0.23 1.40 ± 0.08 1.37 ± 0.09
fAHP Amplitude (mV) ND -7.1 ± 1.4 -7.1 ± 2.2
Time of fAHP (ms) ND 2.2 ± 0.1 2.1 ± 0.2
sAHP Amplitude (mV) -10.5 ± 2.0 -10.3 ± 0.8 -9.2 ± 1.6
Time of sAHP (ms) 65.8 ± 11.4 68.5 ± 9.4 59.8 ± 8.3
ADP (mV) ND 9.7 ± 1.3a 13.1 ± 3.3a, b
Pinch-evoked responses higher than 200% 1/5 (20%) 10/31 (32%) 7/14 (50%)
  1. Values are means ± SEM.
  2. n is number of cells.
  3. ACC, anterior cingulate cortex; RMP, resting membrane potential; fAHP, fast afterhyperpolarization; sAHP, slow afterhyperpolarization; ADP, afterdepolarization.
  4. a Significantly different from RS cells at P < 0.001.
  5. ND indicates no data.
  6. b Significantly different from IM cells at P < 0.05.