In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice

Table 1 Summary of basic electrophysiological parameters of ACC layer II/III pyramidal neurons in adult mice in vivo

	*RS cells (n = 5)*	*IM cells (n = 31)*	*IB cells (n = 14)*
*Ratio*	10	62	28
*RMP (mV)*	-68.4 ± 2.2	-72.0 ± 1.9	-67.1 ± 2.3
*Spontaneous AP threshold (mV)*	-46.1 ± 2.9	-48.3 ± 1.4	-44.2 ± 2.0
*Oscillation Frequency (Hz)*	0.4 ± 0.08	0.41 ± 0.04	0.48 ± 0.04
*Spike Height (mV)*	56.1 ± 7.5	59.0 ± 2.3	57.5 ± 3.2
*Spike Half Width (ms)*	1.40 ± 0.23	1.40 ± 0.08	1.37 ± 0.09
*fAHP Amplitude (mV)*	ND	-7.1 ± 1.4	-7.1 ± 2.2
*Time of fAHP (ms)*	ND	2.2 ± 0.1	2.1 ± 0.2
*sAHP Amplitude (mV)*	-10.5 ± 2.0	-10.3 ± 0.8	-9.2 ± 1.6
*Time of sAHP (ms)*	65.8 ± 11.4	68.5 ± 9.4	59.8 ± 8.3
*ADP (mV)*	ND	9.7 ± 1.3^a	13.1 ± 3.3^{a, b}
*Pinch-evoked responses higher than 200%*	1/5 (20%)	10/31 (32%)	7/14 (50%)

Values are means ± SEM.
n is number of cells.
ACC, anterior cingulate cortex; RMP, resting membrane potential; fAHP, fast afterhyperpolarization; sAHP, slow afterhyperpolarization; ADP, afterdepolarization.
^a Significantly different from RS cells at P < 0.001.
ND indicates no data.
^b Significantly different from IM cells at P < 0.05.

ISSN: 1744-8069