Figure 2From: Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model The effect of intraperitoneal administration of thalidomide on pain-related behaviors produced by bone cancer pain. PWMT to von Frey filament stimulation (A) and PWTL to thermal stimulation stimulation (B) were ameliorated after treatment with thalidomide. Thalidomide (50 mg/kg) was applied on 1 d after operation and then once daily thereafter until day 7. Thalidomide alone did not affect the behavior response in sham mice (A, B). All data points represent mean ± SD (n = 6 per group). * P < 0.05 vs tumor + vehicle group.Back to article page