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Figure 5 | Molecular Pain

Figure 5

From: Expression of inwardly rectifying potassium channels by an inducible adenoviral vector reduced the neuronal hyperexcitability and hyperalgesia produced by chronic compression of the spinal ganglion

Figure 5

AdKir reversed the CCD-induced hyperexcitability in DRG neurons. Typical intracellular recordings (Vm) were obtained from the somata of DRG neurons transfected with AdEGI (A), AdEGI plus CCD surgery (B) or AdKir plus CCD surgery (C). Current steps (Ic) were injected to obtain the rheobase and input resistance. All three neurons are Aβ-type with large-diameter somata. The rheobase of DRG neurons with control vector AdEGI decreased remarkably after CCD surgery, but this effect was reversed by AdKir.

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