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Figure 6 | Molecular Pain

Figure 6

From: Behavioral and anatomical characterization of the bilateral sciatic nerve chronic constriction (bCCI) injury: correlation of anatomic changes and responses to cold stimuli

Figure 6

Superficial dorsal horn immunohistochemical staining for CCK. (A) Representative photomicrographs of dorsal horn immunoreactivity for cholecystokinin (CCK) in sham operated rats (Sham CCK) versus bCCI rats on post-ligation day 15. Scale bar represents 100 μM. Medial area of the dorsal horn shows greatest decrease in staining in bCCI rats compared to sham-operated controls. (B) Dorsal horn CCK staining densitometry at various postoperative days compared as a percentage of staining in naïve rats. CCK peptide staining decreased at all the time points studied (p < 0.001; F = 68.3; df = 1; Two way ANOVA). CCK -8 showed decrease in immunoreactivity in day 15 (p = 0.001; post hoc Tukey Test) followed by a slight increase at day 30 (p = 0.02; post hoc Tukey test) and then a marked and consistent decrease thereafter to day 90 compared to sham operated rats (p < 0.001; post hoc Tukey test). Data points are group means +/- SEM.

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Molecular Pain

ISSN: 1744-8069

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