Figure 4

Both μ- and δ-opioids inhibit icilin enhanced glutamatergic transmission. (a) Time plot of miniature EPSC (mEPSC) rate during superfusion of icilin (100 μM), then during addition of DAMGO (3 μM), CTAP (1 μM), deltorphin-II (Delt, 300 nM), ICI-174864 (ICI, 1 μM) and U69593 (U69, 300 nM). (b) Averaged traces and (c) raw current traces of mEPSCs prior to (Pre), and during icilin, then during addition of deltorphin-II, U69593 and DAMGO. Cumulative probability distribution plots of mEPSC (d) inter-event interval and (e) amplitude for the epochs averaged in (b) (number of events = 155, 372, 91, 343, 438 for control, icilin, DAMGO, deltorphin-II and U69593 over 60, 44, 52, 64 and 48 s intervals, respectively). (a) - (e) are taken from one neuron.