TY - JOUR AU - Portenoy, R. K. AU - Lesage, P. PY - 1999 DA - 1999// TI - Management of cancer pain JO - Lancet VL - 353 UR - https://doi.org/10.1016/S0140-6736(99)01310-0 DO - 10.1016/S0140-6736(99)01310-0 ID - Portenoy1999 ER - TY - JOUR AU - Caraceni, A. AU - Portenoy, R. K. PY - 1999 DA - 1999// TI - An international survey of cancer pain characteristics and syndromes JO - Pain VL - 82 UR - https://doi.org/10.1016/S0304-3959(99)00073-1 DO - 10.1016/S0304-3959(99)00073-1 ID - Caraceni1999 ER - TY - JOUR AU - Laird, B. AU - Colvin, L. AU - Fallon, M. PY - 2008 DA - 2008// TI - Management of cancer pain: basic principles and neuropathic cancer pain JO - European Journal of Cancer VL - 44 UR - https://doi.org/10.1016/j.ejca.2008.03.022 DO - 10.1016/j.ejca.2008.03.022 ID - Laird2008 ER - TY - JOUR AU - Foley, K. M. PY - 1988 DA - 1988// TI - Pain syndromes and pharmacologic management of pancreatic cancer pain JO - Journal of Pain and Symptom Management VL - 3 UR - https://doi.org/10.1016/0885-3924(88)90028-0 DO - 10.1016/0885-3924(88)90028-0 ID - Foley1988 ER - TY - JOUR AU - Negus, S. S. AU - Vanderah, T. W. AU - Brandt, M. R. AU - Bilsky, E. J. AU - Becerra, L. AU - Borsook, D. PY - 2006 DA - 2006// TI - Preclinical assessment of candidate analgesic drugs: recent advances and future challenges JO - The Journal of Pharmacology and Experimental Therapeutics VL - 319 UR - https://doi.org/10.1124/jpet.106.106377 DO - 10.1124/jpet.106.106377 ID - Negus2006 ER - TY - JOUR AU - Meyer, T. AU - Caplin, M. E. AU - Palmer, D. H. AU - Valle, J. W. AU - Larvin, M. AU - Wates, J. S. AU - Coxon, F. AU - Borbath, I. AU - Peeters, M. AU - Nagano, E. AU - Kato, H. PY - 2010 DA - 2010// TI - A phase Ib/IIa trial to evaluate the CCK2 receptor antagonist Z-360 in combination with gemcitabine in patients with advanced pancreatic cancer JO - European Journal of Cancer VL - 46 UR - https://doi.org/10.1016/j.ejca.2009.11.004 DO - 10.1016/j.ejca.2009.11.004 ID - Meyer2010 ER - TY - JOUR AU - Kawasaki, D. AU - Emori, Y. AU - Eta, R. AU - Iino, Y. AU - Hamano, H. AU - Yoshinaga, K. AU - Tanaka, T. AU - Takei, M. AU - Watson, S. A. PY - 2008 DA - 2008// TI - Effect of Z-360, a novel orally active CCK-2/gastrin receptor antagonist on tumor growth in human pancreatic adenocarcinoma cell lines in vivo and mode of action determinations in vitro JO - Cancer Chemotherapy and Pharmacology VL - 61 UR - https://doi.org/10.1007/s00280-007-0591-8 DO - 10.1007/s00280-007-0591-8 ID - Kawasaki2008 ER - TY - JOUR AU - Grabowska, A. M. AU - Morris, T. M. AU - McKenzie, A. J. AU - Kumari, R. AU - Hamano, H. AU - Emori, Y. AU - Yoshinaga, K. AU - Watson, S. A. PY - 2008 DA - 2008// TI - Pre-clinical evaluation of a new orally-active CCK-2R antagonist, Z-360, in gastrointestinal cancer models JO - Regulatory Peptides VL - 146 UR - https://doi.org/10.1016/j.regpep.2007.08.007 DO - 10.1016/j.regpep.2007.08.007 ID - Grabowska2008 ER - TY - JOUR AU - Kobayashi, N. AU - Seto, K. AU - Orikawa, Y. AU - Hamano, H. AU - Yoshinaga, K. AU - Takei, M. PY - 2010 DA - 2010// TI - Z-360, a novel cholecystokinin-2/gastrin receptor antagonist, inhibits gemcitabine-induced expression of the vascular endothelial growth factor gene in human pancreatic cancer cells JO - Biological & Pharmaceutical Bulletin VL - 33 UR - https://doi.org/10.1248/bpb.33.216 DO - 10.1248/bpb.33.216 ID - Kobayashi2010 ER - TY - JOUR AU - Yoshinaga, K. AU - Horii, T. AU - Hamano, H. AU - Eta, R. AU - Ozaki, T. AU - Orikawa, Y. AU - Yoshii, K. AU - Kawabata, Y. AU - Hori, Y. AU - Seto, K. AU - Takei, M. AU - Kuraishi, Y. PY - 2010 DA - 2010// TI - Pharmacological evaluation of analgesic effects of Cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain JO - Biological & Pharmaceutical Bulletin VL - 33 UR - https://doi.org/10.1248/bpb.33.244 DO - 10.1248/bpb.33.244 ID - Yoshinaga2010 ER - TY - JOUR AU - Sasamura, T. AU - Nakamura, S. AU - Iida, Y. AU - Fujii, H. AU - Murata, J. AU - Saiki, I. AU - Nojima, H. AU - Kuraishi, Y. PY - 2002 DA - 2002// TI - Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation JO - European Journal of Pharmacology VL - 441 UR - https://doi.org/10.1016/S0014-2999(02)01450-4 DO - 10.1016/S0014-2999(02)01450-4 ID - Sasamura2002 ER - TY - JOUR AU - Zhang, H. W. AU - Iida, Y. AU - Andoh, T. AU - Nojima, H. AU - Murata, J. AU - Saiki, I. AU - Kuraishi, Y. PY - 2003 DA - 2003// TI - Mechanical hypersensitivity and alterations in cutaneous nerve fibers in a mouse model of skin cancer pain JO - Journal of Pharmacological Science VL - 91 UR - https://doi.org/10.1254/jphs.91.167 DO - 10.1254/jphs.91.167 ID - Zhang2003 ER - TY - JOUR AU - Kuraishi, Y. AU - Iida, Y. AU - Zhang, H. W. AU - Uehara, S. AU - Nojima, H. AU - Murata, J. AU - Saiki, I. AU - Takahata, H. AU - Ouchi, H. PY - 2003 DA - 2003// TI - Suppression by gabapentin of pain-related mechano-responses in mice given orthotopic tumor inoculation JO - Biological & Pharmaceutical Bulletin VL - 26 UR - https://doi.org/10.1248/bpb.26.550 DO - 10.1248/bpb.26.550 ID - Kuraishi2003 ER - TY - JOUR AU - Slack, S. AU - Battaglia, A. AU - Cibert-Goton, V. AU - Gavazzi, I. PY - 2008 DA - 2008// TI - EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia JO - Neuroscience VL - 156 UR - https://doi.org/10.1016/j.neuroscience.2008.07.023 DO - 10.1016/j.neuroscience.2008.07.023 ID - Slack2008 ER - TY - JOUR AU - Calò, L. AU - Cinque, C. AU - Patanè, M. AU - Schillaci, D. AU - Battaglia, G. AU - Melchiorri, D. AU - Nicoletti, F. AU - Bruno, V. PY - 2006 DA - 2006// TI - Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration JO - Journal of Neurochemistry VL - 98 UR - https://doi.org/10.1111/j.1471-4159.2006.03844.x DO - 10.1111/j.1471-4159.2006.03844.x ID - Calò2006 ER - TY - JOUR AU - Song, X. J. AU - Zheng, J. H. AU - Cao, J. L. AU - Liu, W. T. AU - Song, X. S. AU - Huang, Z. J. PY - 2008 DA - 2008// TI - EphrinB-EphB receptor signalling contributes to neuropathic pain by regulating neural excitability and spinal synaptic plasticity in rats JO - Pain VL - 139 UR - https://doi.org/10.1016/j.pain.2008.03.019 DO - 10.1016/j.pain.2008.03.019 ID - Song2008 ER - TY - JOUR AU - Uchida, H. AU - Matsumoto, M. AU - Ueda, H. PY - 2009 DA - 2009// TI - Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid: ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia JO - Neurochemistry International VL - 54 UR - https://doi.org/10.1016/j.neuint.2008.11.004 DO - 10.1016/j.neuint.2008.11.004 ID - Uchida2009 ER - TY - JOUR AU - Kabir, S. AU - Grant, C. AU - Daar, A. S. PY - 1995 DA - 1995// TI - Serum levels of interleukin-1, interleukin-6 and tumour necrosis factor-alpha in patients with gastric carcinoma JO - Cancer Letters VL - 95 UR - https://doi.org/10.1016/0304-3835(95)03895-4 DO - 10.1016/0304-3835(95)03895-4 ID - Kabir1995 ER - TY - JOUR AU - Hamacher, R. AU - Diersch, S. AU - Scheibel, M. AU - Eckel, F. AU - Mayr, M. AU - Rad, R. AU - Bajbouj, M. AU - Schmid, R. M. AU - Saur, D. AU - Schneider, G. PY - 2009 DA - 2009// TI - Interleukin 1 beta gene promoter SNPs are associated with risk of pancreatic cancer JO - Cytokine VL - 46 UR - https://doi.org/10.1016/j.cyto.2009.01.005 DO - 10.1016/j.cyto.2009.01.005 ID - Hamacher2009 ER - TY - JOUR AU - Dinarello, C. A. PY - 1996 DA - 1996// TI - Biologic basis for interleukin-1 in disease JO - Blood VL - 87 ID - Dinarello1996 ER - TY - JOUR AU - Apte, R. N. AU - Dotan, S. AU - Elkabets, M. AU - White, M. R. AU - Reich, E. AU - Carmi, Y. AU - Song, X. AU - Dvozkin, T. AU - Krelin, Y. AU - Voronov, E. PY - 2006 DA - 2006// TI - The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions JO - Cancer Metastasis Reviews VL - 25 UR - https://doi.org/10.1007/s10555-006-9004-4 DO - 10.1007/s10555-006-9004-4 ID - Apte2006 ER - TY - JOUR AU - Zelenka, M. AU - Schafers, M. AU - Sommer, C. PY - 2005 DA - 2005// TI - Intraneural injection of interleukin-1 beta and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain JO - Pain VL - 116 UR - https://doi.org/10.1016/j.pain.2005.04.018 DO - 10.1016/j.pain.2005.04.018 ID - Zelenka2005 ER - TY - JOUR AU - Honore, P. AU - Wade, C. L. AU - Zhong, C. AU - Harris, R. R. AU - Wu, C. AU - Ghayur, T. AU - Iwakura, Y. AU - Decker, M. W. AU - Faltynek, C. AU - Sullivan, J. AU - Jarvis, M. F. PY - 2006 DA - 2006// TI - Interleukin-1αβ gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain JO - Behavioural Brain Research VL - 167 UR - https://doi.org/10.1016/j.bbr.2005.09.024 DO - 10.1016/j.bbr.2005.09.024 ID - Honore2006 ER - TY - JOUR AU - Zhang, R. X. AU - Liu, B. AU - Li, A. AU - Wang, L. AU - Ren, K. AU - Qiao, J. T. AU - Berman, B. M. AU - Lao, L. PY - 2008 DA - 2008// TI - Interleukin 1β facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation JO - Neuroscience VL - 154 UR - https://doi.org/10.1016/j.neuroscience.2008.04.072 DO - 10.1016/j.neuroscience.2008.04.072 ID - Zhang2008 ER - TY - JOUR AU - Zhang, R. X. AU - Li, A. AU - Liu, B. AU - Wang, L. AU - Ren, K. AU - Zhang, H. AU - Berman, B. M. AU - Lao, L. PY - 2008 DA - 2008// TI - IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats JO - Pain VL - 135 UR - https://doi.org/10.1016/j.pain.2007.05.023 DO - 10.1016/j.pain.2007.05.023 ID - Zhang2008 ER - TY - JOUR AU - Schafers, M. AU - Brinkhoff, J. AU - Neukichen, S. AU - Marziniak, M. AU - Sommer, C. PY - 2001 DA - 2001// TI - Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuroptahic pain in mice JO - Neurosci Lett VL - 310 UR - https://doi.org/10.1016/S0304-3940(01)02077-8 DO - 10.1016/S0304-3940(01)02077-8 ID - Schafers2001 ER - TY - JOUR AU - Sweitzer, S. AU - Martin, D. AU - DeLeo, J. A. PY - 2001 DA - 2001// TI - Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain JO - Neuroscience VL - 103 UR - https://doi.org/10.1016/S0306-4522(00)00574-1 DO - 10.1016/S0306-4522(00)00574-1 ID - Sweitzer2001 ER - TY - JOUR AU - Nakazawa, T. AU - Komai, S. AU - Tezuka, T. AU - Hisatsune, C. AU - Umemori, H. AU - Semba, K. AU - Mishina, M. AU - Manabe, T. AU - Yamamoto, T. PY - 2001 DA - 2001// TI - Characterization of Fyn-mediated tyrosine phosphorylation sites on GluRε2 (NR2B) subunit of the N- Methyl-D-aspartate receptor JO - The Journal of Biological Chemistry VL - 276 UR - https://doi.org/10.1074/jbc.M008085200 DO - 10.1074/jbc.M008085200 ID - Nakazawa2001 ER - TY - JOUR AU - Fujita, M. AU - Andoh, T. AU - Ohashi, K. AU - Akira, A. AU - Saiki, I. AU - Kuraishi, Y. PY - 2009 DA - 2009// TI - Roles of kinin B1 and B2 receptors in skin cancer pain produced by orthotopic melanoma inoculation in mice JO - European Journal of Pain VL - 14 UR - https://doi.org/10.1016/j.ejpain.2009.10.010 DO - 10.1016/j.ejpain.2009.10.010 ID - Fujita2009 ER - TY - JOUR AU - Parsons, C. G. PY - 2001 DA - 2001// TI - NMDA receptors as targets for drug action in neuropathic pain JO - European Journal of Pharmacology VL - 429 UR - https://doi.org/10.1016/S0014-2999(01)01307-3 DO - 10.1016/S0014-2999(01)01307-3 ID - Parsons2001 ER - TY - JOUR AU - Petrenko, A. B. AU - Yamakura, T. AU - Baba, H. AU - Shimoji, K. PY - 2003 DA - 2003// TI - The role of N- Methyl-D-Aspartate (NMDA) receptors in pain: a review JO - Anesthesia and analgesia VL - 97 UR - https://doi.org/10.1213/01.ANE.0000081061.12235.55 DO - 10.1213/01.ANE.0000081061.12235.55 ID - Petrenko2003 ER - TY - JOUR AU - Guo, W. AU - Wei, F. AU - Zou, S. AU - Robbins, M. T. AU - Sugiyo, S. AU - Ikeda, T. AU - Tu, J. C. AU - Worley, P. F. AU - Dubner, R. AU - Ren, K. PY - 2004 DA - 2004// TI - Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia JO - The Journal of Neuroscience VL - 24 UR - https://doi.org/10.1523/JNEUROSCI.3422-04.2004 DO - 10.1523/JNEUROSCI.3422-04.2004 ID - Guo2004 ER - TY - JOUR AU - Cunningham, M. E. AU - Shaw-Stiffel, T. A. AU - Bernstein, L. H. AU - Tinghitella, T. J. AU - Claus, R. E. AU - Brogan, D. A. AU - McMillen, M. A. PY - 1995 DA - 1995// TI - Cholecystokinin-stimulated monocytes produce inflammatory cytokines and eicosanoids JO - The American Journal of Gastroenterology VL - 90 ID - Cunningham1995 ER - TY - JOUR AU - Fruscella, P. AU - Sottocorno, M. AU - Braccio, M. D. AU - Diomede, L. AU - Piccardi, N. AU - Cagnotto, A. AU - Grossi, G. AU - Romano, M. AU - Mennini, T. AU - Roma, G. PY - 2001 DA - 2001// TI - 1,5-Benzodiazepine tricyclic derivatives exerting anti-inflammatory effects in mice by inhibiting interleukin-6 and prostaglandin E2 production JO - Pharmacol Research VL - 43 UR - https://doi.org/10.1006/phrs.2001.0800 DO - 10.1006/phrs.2001.0800 ID - Fruscella2001 ER - TY - JOUR AU - Grossi, G. AU - Braccio, M. D. AU - Roma, G. AU - Ballabeni, V. AU - Tognolini, M. AU - Calcina, F. AU - Barocelli, E. PY - 2002 DA - 2002// TI - 1,5-Benzodiazepines part XIII. Substituted 4H-[1,2,4] triazolo[4,3-a][1,5]benzodiazepine-5-amines and 4H-imidazo[1,2-a][1,5]benzodiazepine-5 amines as analgesic, anti-inflammatory and/or antipyretic agents with low acute toxicity JO - Eur J Med Chem VL - 37 UR - https://doi.org/10.1016/S0223-5234(02)01400-9 DO - 10.1016/S0223-5234(02)01400-9 ID - Grossi2002 ER - TY - BOOK AU - Baba, Y. AU - Brown, K. C. AU - Goehring, R. R. AU - Tsuno, N. PY - 2008 DA - 2008// TI - Preparation of piperidinylquinoxalinedione derivatives and analogs as analgesics ID - Baba2008 ER - TY - BOOK AU - Joergensen, T. K. AU - Andersen, K. E. AU - Andersen, H. S. AU - Hohlweg, R. AU - Madsen, P. AU - Olsen, U. B. PY - 1996 DA - 1996// TI - Novel heterocyclic compounds for treatment of pain and/or inflammation ID - Joergensen1996 ER - TY - BOOK AU - Zhang, J. AU - Benedetti, Y. AU - Commercon, A. PY - 2007 DA - 2007// TI - New heterocyclic 2-alkoxy-3,4,5-trihydroxy-alkylamide derivatives are angiogenesis inhibitors-useful for the treatment of cancer, rheumatoid arthritis, osteoarthritis, inflammatory intestinal disorders, eye disorders, chronic inflammation and psoriasis ID - Zhang2007 ER - TY - BOOK AU - Szewczyk, J. R. AU - Donaldson, K. H. PY - 2006 DA - 2006// TI - New benzodiazepine compounds are melanocortin MC4 agonists-useful for the treatment of obesity, diabetes mellitus, inflammation, depression and anxiety disorder ID - Szewczyk2006 ER - TY - BOOK AU - Flohr, A. AU - Jakob-Roetne, R. AU - Wostl, W. PY - 2008 DA - 2008// TI - New 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives are gamma-secretase inhibitors -useful for the prevention and treatment of Alzheimer's diseases ID - Flohr2008 ER - TY - BOOK AU - Oshima, K. AU - Oshiyama, T. AU - Taira, S. AU - Menjo, Y. AU - Yamabe, H. PY - 2009 DA - 2009// TI - New substituted benzodiazepine derivatives are Kv1.5 and GIRK1/4 channel inhibitors- useful for the treatment of arrhythmia ID - Oshima2009 ER -