Skip to main content
Figure 2 | Molecular Pain

Figure 2

From: Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice

Figure 2

Effects of Z-360 on ephrin B1 and Eph B1 receptor gene expression in DRGs. B16/BL6 melanoma cells were injected into the plantar region of the right hind paw of C57BL/6 mice, and Z-360 (100 mg/kg) was then administered orally once a day from day 7 after transplantation. A final oral administration of Z-360 was given to mice 60 min prior to the collection of L4-5 DRG samples on day 14 after transplantation. Gene expression analysis for ephrin B1 (A) and the Eph B1 receptor (B) were performed by quantitative real-time RT-PCR. Data represent -fold changes versus the mean for normal mice. Columns represent the mean ± S.E. (n = 12). ###, p < 0.001, versus normal (t-test). ***, p < 0.001, versus vehicle (t-test).

Back to article page