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Figure 5 | Molecular Pain

Figure 5

From: Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice

Figure 5

Effects of IL-1β injection on ephrin B1 and Eph B1 receptor gene expression in DRGs. Recombinant IL-1β (300 or 1000 pg/paw) was injected into the plantar region of the right hind paw of C57BL/6 mice, and L4-5 DRG samples were then collected after 60 min. Gene expression analysis for ephrin B1 (A) and the Eph B1 receptor (B) were performed by quantitative real-time RT-PCR. Data represent fold changes versus the mean for saline-injected control mice. Columns represent the mean ± S.E. (n = 4). *, p < 0.05, versus saline (non-parametric Dunnett's test).

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Molecular Pain

ISSN: 1744-8069

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