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Figure 7 | Molecular Pain

Figure 7

From: Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice

Figure 7

Effect of sulfated CCK-8 on IL-1β production in the cancer-inoculated region. B16/BL6 cells were injected into the plantar region of the right hind paw of C57BL/6 mice, and sulfated CCK-8 (10 or 30 μg/kg) was then administered by intraperitoneal injection twice a day from day 7 after transplantation. On day 10 after transplantation, a final dose of sulfated CCK-8 was administered to mice 30 min prior to the collection of right hind paw samples, which were the homogenized and subjected to ELISA for the measurement of IL-1β. The data are reported as the mean ± S.E. (n = 11-12). ##, p < 0.01, versus saline (non-parametric Dunnett's test).

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Molecular Pain

ISSN: 1744-8069

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