Antialgesic nociceptive response in the inflammation and thermonociception groups measured as paw withdrawal latency (PWL) in s after a thermonociceptive stimulus. The figure shows PWL before the induction of inflammation with carrageenan 1% (250 μl) in the inflammation group in the first set of bars. The second and third sets of bars show PWL 1 h and 3 h after inflammation, respectively. The thermonociception groups did not have inflammation induced and were tested in parallel with the inflammation group. Notice that the inflammation group has no difference in PWL before inflammation compared to the thermonociception group and shows a progressively decreased PWL 1 h (t = -2.335, p = 0.035) and 3 h (t = -9.938, p < 0.001) thereafter.