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Figure 2 | Molecular Pain

Figure 2

From: Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain

Figure 2

Neural marker expression was normal in DRG neurons of ephrin-B2 CKO mice. (A) Whole DRG sections of Efnb2 CKO mutant mice and Efnb2fl/fl littermate controls were labeled with anti-peripherin (green) and anti-neurofilament (red) antibodies. The right panels are merged images of the left and middle panels. (B) DRG sections were also labeled with anti-CGRP (red) and anti-IB4 (red) antibodies, co-labeled with anti-βIII-tubulin (green). The right panels are erged images of the left and middle panels. (C) The proportions of CGRP, IB4 and neurofilament (N52) expressing neurons were normal in Efnb2 CKO animals compared to Efnb2fl/fl littermate controls. (D) Cross section of lumbar spinal cord (L3 - L5) stained with anti-CGRP (green) antibody and anti-IB4 (red) antibody. In laminae I-II, both CGRP positive terminals and IB4 positive terminals were identified in the Efnb2 CKO mutant mice and Efnb2fl/fl littermate controls. Scale bar = 50 μm.

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