Figure 5

Subcutaneous injection of LPS in the lower lip induced microglial activation in the brain. In response to local LPS administration, microglial activation was first observed in the CVOs, such as the area postrema (AP) and at the edge of the grey matter at 5 hours post-injection. At 48 hours, activated microglia were dispersed throughout the parenchyma. Activated microglia exhibited remarkable changes in microglial morphology (inserts). Diagrams were adapted and modified from [59]. Orange shadowed area indicated where the pictures were taken. Scale bar: 50 μm.