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Figure 5 | Molecular Pain

Figure 5

From: Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice

Figure 5

KOR activation in TREZ at day 8 after pIONL. (A), KOR-p-IR in sham operated WT mice. (B, C), increased KOR-p staining was seen within the root entry zone on the ipsilateral side compared to contralateral side following pIONL in WT mice. KOR activation was blocked by the deletion of kappa opioid receptor or norBNI treatment (D, E). (F), Mean ± SEM pixel intensity of KOR-p intensity in TREZ at day 8 after pIONL. (G-I), Double immunohistochemistry for KOR-p and GFAP in the TREZ at day 8 after pIONL. KOR-p staining is completely overlapped with GFAP staining. (*p < 0.001) Scale bars: A-E, 30 μm; G-I, 50 μm.

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