Figure 7
From: Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice
Cell proliferation in TREZ 8 d after pIONL. (A) Data came from TREZ (the area shown in red box). (B, C, F), the number of BrdU positive nuclei increased in both ipsilateral and contralateral TREZ following pIONL in WT compared to sham operated mice. (B-H), in the ipsilateral TREZ, KOR-/- and norBNI treated mice showed BrdU positive nuclei more than twice as much as that in WT mice. Similar to the result from Vp, the majority of BrdU positive nuclei was double-labeled with CD11b or Nestin in the CNS side of TREZ. Neither GFAP or S100beta-IR was double labeled with BrdU-IR (I-P). (*p < 0.001) Scale bars: A, 250 μm, C-H, 50 μm, I-P, 30 μm.