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Table 2 Main effects, by VOI, detected by mixed effects analysis

From: "First pain" in humans: convergent and specific forebrain responses

  

A. 51°C stimulation

B. 41°C stimulation

Structure

Side

# voxels

z-score

Coordinates (Tal)

# voxels

z-score

Coordinates (Tal)

    

x

y

z

  

x

y

z

Lateral thalamus

C

     

65

3.6

22

-12

-1

Anterior insula

C

136

3.08

30

10

0

386

3.7

32

18

5

 

I

117

3.66

-32

11

-6

141

3.8

-34

16

5

Posterior insula

C

     

269

4.2

30

-19

5

 

I

83

3.48

-42

-5

19

     

POFC

C

119

3.6

40

25

2

441

3.6

42

29

-3

 

C

38

3.2

24

25

-13

     
 

I

46

3.32

-28

21

-8

154

3.5

-28

32

-13

aMCC

C

81

2.85

10

31

35

172

3.6

6

27

34

 

C

     

101

3.6

6

9

22

 

I

     

113

3.7

-10

13

21

pMCC

C

     

18

3

10

-8

30

pACC

C

23

3.15

10

39

0

     
 

I

35

3.06

-10

38

18

48

3.1

-10

43

2

S1

C

     

86

3.5

51

-26

47

 

C

     

34

2.8

32

-40

54

 

I

     

76

3.5

-14

-25

49

S2

C

32

3.7

57

-17

19

103

4.8

59

-15

17

Hypothalamus

C

     

17

3.1

6

-12

-8

 

C

     

19

3.1

14

0

-8

 

C

     

32

3.1

10

1

-10

 

I

17

2.67

-10

-8

-6

35

3.2

-10

-12

-8

Hippocampus

C

41

3.48

22

-28

-10

46

3.3

24

-45

-4

 

C

     

120

3.7

22

-26

-7

 

C

     

68

3.4

36

-14

-13

 

C

     

70

3

22

-13

-18

 

I

     

33

2.8

-22

-14

-18

  1. (A) Activations during 51°C stimulation. (B) Activations during 41°C stimulation. Each line represents a cluster within the corresponding VOI. I: ipsilateral to stimulation, C: contralateral to stimulation. Coordinates are based on the stereotactic atlas by Talairach & Tournoux [19].
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Molecular Pain

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