Morphological effects of oxaliplatin treated neurons. A. Dose-related decrease in maximum neurite length in oxaliplatin treated adult rat DRG neurons in vitro; 33% reduction after 5 μg/ml oxaliplatin, 42.7% reduction after 20 μg/ml, and 75% reduction after 50 μg/ml oxaliplatin treatment. B. Decrease in the percentage of Gap43 positive neurons bearing neurites (solid bars) and increased proportion of neurons without neurites (clear bars) after treatment with increasing oxaliplatin concentration. C. The number of neurons surviving after 48 hours oxaliplatin treatment, expressed as a percentage of vehicle treated neurons was significantly reduced after treatment with 5, 20 and 50 μg/ml oxaliplatin.