Figure 2

Influence of dosing-time on the anti-allodynic effects of gabapentin in PSL mice. (A) Time course of PWT in PSL mice after i.p. injection with 50, 100 and 150 mg/kg gabapentin or saline on day 7 after nerve injury. Values are shown as means with S.E.M. (n = 6). *P < 0.05 compared with saline-treated group. (B) Dosing time-dependence of anti-allodynic effects of gabapentin in PSL mice. Gabapentin (100 mg/kg, i.p.) was injected into PSL mice at 17:00 or 5:00. The AUC of PWT after gabapentin injection was calculated using trapezoidal rule. Values are shown as means with S.E.M. (n = 6). In left panel, *P < 0.05 compared with 17:00 group at corresponding dosing time. In right panel, *P < 0.05 compared between two groups. (C) Comparison of normalized PWT (left) and AUC (right) after gabapentin (100 mg/kg, i.p.) injection. *P < 0.05 compared with 17:00 group at corresponding dosing time.