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Figure 6 | Molecular Pain

Figure 6

From: Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain

Figure 6

Expression of α2δ-1 in DRG of PSL mice varies over 24 h. (A) Temporal expression profile for α2δ-1 protein in contralateral and ipsilateral DRG of PSL mice. Values are normalized by protein levels of ACTIN. Values are shown as means with S.E.M. (n = 3). *P < 0.05 compared with contralateral side at corresponding time points. Levels of α2δ-1 protein significantly varied over 24 h in ipsilateral DRG (P < 0.05; ANOVA). Left panel shows representative western blots of α2δ-1 protein in contralateral and ipsilateral DRG of PSL mice. (B) Temporal expression profile of α2δ-1 (left) and α1A (right) mRNA in contralateral and ipsilateral DRG of PSL mice. Values are shown as means with S.E.M. (n = 4-6). *P < 0.05 compared with contralateral side at corresponding time points. Levels of α2δ-1 mRNA significantly varied over 24 h in ipsilateral DRG (P < 0.05; ANOVA).

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Molecular Pain

ISSN: 1744-8069

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